A recent study suggests that people who stop using popular slimming jabs like semaglutide or tirzepatide can put back on lost weight much more quickly than those who halt traditional lifestyle programs.
Findings released in a major medical journal points out that while obese individuals can lose about a fifth of their body weight while undergoing treatment, the mass returns at an average rate of 0.8 kg per month once they quit.
"People buying such drugs must be aware of the risk of rapid rebound weight gain when the therapy is stopped," cautioned researcher Dr. Susan Jebb.
Such speed of regain suggests a reversion to pre-treatment weight within about one and a half years.
Comparing Treatments
The research, which reviewed dozens of trials involving over 9,000 of patients, contrasted the results of the injectable medications with other pills.
Researchers point out that individuals who shed pounds through dieting usually have a slower weight regain—approximately 100 grams monthly—once they finish.
Explaining the Quick Regain
Experts suggest the way of the injections accounts for the heightened weight return.
The injections imitate a body's own chemical called GLP-1, which controls appetite.
"Artificially providing the hormone concentrations far above than normal may cause the system to generate a reduced amount of its own natural hormone, and could lessen sensitivity to its effects," noted Dr. Adam Collins, a dietetics expert.
"Withdrawal of this medication results in appetite is uncontrolled, making overeating far more likely."
A Lifelong Disease?
Medical guidelines recommend the jabs for individuals with obesity-related medical conditions, alongside recommended lifestyle changes.
A number of clinicians say that, given the likelihood of relapse, the therapy might need to be life-long.
This perspective is echoed by drug manufacturers, who state that the results "highlight the persistent nature of excess weight," akin to managing conditions like diabetes.
Patient Accounts
People who have come off the jabs describe a intense return of hunger.
"I experienced a switch that goes on and you become extremely hungry," described one woman.
This difficulty is worsened if individuals have not established lasting lifestyle or habit modifications during treatment.
Widespread Adoption
Survey data indicate that millions of people in the UK have used weight-loss jabs in the last 12 months, with interest being substantial.
- Adoption is higher among females compared to men.
- The 40s and 50s age group shows the greatest level of interest.
- Many obtain the medications through private prescriptions rather than the NHS.
Finally, experts emphasize that while these medications are powerful tools for shedding pounds, they are not a magic solution and lasting health benefits hinges on integrated lifestyle support.
